A NOVEL AND PRACTICAL METHOD FOR HYDROCYANATION OF CHALCONES

Authors
ELLIS JE DAVIS EM BROWER PL
Citation
Je. Ellis et al., A NOVEL AND PRACTICAL METHOD FOR HYDROCYANATION OF CHALCONES, Organic process research & development, 1(3), 1997, pp. 250-252
Citations number
12
Journal title
Organic process research & development → ACNP
ISSN journal
10836160
Volume
1
Issue
3
Year of publication
1997
Pages
250 - 252
Database
ISI
SICI code
1083-6160(1997)1:3<250:ANAPMF>2.0.ZU;2-K
Abstract
A novel and practical method for the hydrocyanation of chalcones is de scribed, The chalcone hydrocyanation reaction proceeds very efficientl y using only 125 mol % of acetone cyanohydrin and 5 mol % of tetrameth ylammonium hydroxide. This reaction stoichiometry provides high-qualit y product in good yield on pilot scale, In addition, the reduced amoun ts of acetone cyanohydrin improve the workup, in which the excess cyan ide is destroyed with sodium hypochlorite.