SYNTHESIS UTILIZING INSOLUBLE POLYMERS - NEW REACTIONS AND SMALL MOLECULES

It can be argued that solid-phase organic chemistry is the preferred m ethod of preparing screening libraries for lead compound discovery and lead optimization within the pharmaceutical industry, Solid-phase pep tide chemistry is the most reliable and general of the synthetic metho ds available today; however, the purities of products are inadequate f or the needs of the current market and the screening departments of ph armaceutical companies. Recent synthetic advances in solid-phase organ ic chemistry have started to increase the range of chemistry that can be used to prepare 'drug-like' small molecules in library format.