NEW METHODS FOR ANALYZING COMPOUNDS ON POLYMERIC SUPPORTS

Beyond specialized applications in peptide and oligonucleotide synthes is, widespread utilization of solid-phase methods in organic chemistry has been hampered by a lack of powerful analytical methods for charac terization of polymer-supported compounds. The advent of combinatorial organic synthesis has recently spawned efforts to develop spectroscop ic techniques such as infrared spectrometry, mass spectrometry and nuc lear magnetic resonance as routine tools for structure elucidation in solid-phase synthesis.