KINETICS OF ACTIVE-TRANSPORT IN BIOLOGICAL-MEMBRANES - ROLE OF BARRIER FLUCTUATIONS

Authors
Citation
A. Fulinski, KINETICS OF ACTIVE-TRANSPORT IN BIOLOGICAL-MEMBRANES - ROLE OF BARRIER FLUCTUATIONS, Polish Journal of Chemistry, 71(12), 1997, pp. 1680-1698
Citations number
37
Categorie Soggetti
Chemistry
Journal title
ISSN journal
01375083
Volume
71
Issue
12
Year of publication
1997
Pages
1680 - 1698
Database
ISI
SICI code
0137-5083(1997)71:12<1680:KOAIB->2.0.ZU;2-6
Abstract
The role of barrier fluctuations in the membrane enzymatic processes, among others in the active transport of ions through cell membranes is examined. Membrane electric potential plays the role of a barrier hei ght (activation energy)for enzymes embedded in the cell membrane. This barrier height can be modulated either by internal fluctuations at by superimposed from without external electrical fields, either random o r periodic. Measurements of the changes in reaction yield, or in ionic currents, governed by these enzymes (ionic pumps) can be used as tool s for determining the parameters describing enzymatic action. Barrier fluctuations can change considerably the yield, including the inversio n of the direction of transmembrane currents.