THE SEARCH FOR NEW TRIAZOLE ANTIFUNGAL AGENTS

The first generation antifungal agent triazoles, fluconazole and itrac onazole, have revolutionised the treatment of serious fungal infection s such as mucosal and invasive candidiasis and cryptococcal meningitis . However, the treatment of some fungal infections, particularly asper gillosis, is still far from satisfactory and thus there is an importan t requirement for new broad-spectrum antifungal agents. The new second generation triazoles voriconazole and SCH-56592 show considerable pro mise in achieving this goal in the near future. (C) Current Biology Lt d ISSN 1367-5931.