PRACTICAL SYNTHESIS OF UNSYMMETRICAL POLYAMINE AMIDES

Desymmetrisation of readily available symmetrical polyamines is an imp ortant first step in the synthesis of many polyamine containing natura l products. Likewise in the synthesis of polyamine amides which are po tentially useful for gene delivery and as neuroprotectants, based upon channel blocking toxins found in certain wasp and spider venoms. The application of trifluoroacetyl as a protecting group allows unsymmetri cal polyamine amides to be easily prepared on a gram scale. (C) 1997 E lsevier Science Ltd. All rights reserved.