THE USE OF ALUMINUM-CHLORIDE FOR REMOVAL OF BOC GROUPS ON 5'-AMINO-2',5'-DIDEOXYOLIGONUCLEOTIDES DURING SOLID-PHASE SYNTHESIS

Authors
JAMES KD ELLINGTON AD
Citation
Kd. James et Ad. Ellington, THE USE OF ALUMINUM-CHLORIDE FOR REMOVAL OF BOC GROUPS ON 5'-AMINO-2',5'-DIDEOXYOLIGONUCLEOTIDES DURING SOLID-PHASE SYNTHESIS, Tetrahedron letters, 39(3-4), 1998, pp. 175-178
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
3-4
Year of publication
1998
Pages
175 - 178
Database
ISI
SICI code
0040-4039(1998)39:3-4<175:TUOAFR>2.0.ZU;2-M
Abstract
A method for the facile removal of the t-butoxycarbonyl (Boc) group wi th aluminum chloride during solid-phase oligonucleotide synthesis is p resented. The method enables the common amino protecting group, which is stable to base and weak acid, to be removed with no threat to the i ntegrity of the oligonucleotide. The suitability of several other Lewi s acids for this procedure is discussed. (C) 1997 Elsevier Science Ltd . All rights reserved.