CLEAVAGE OF TERT-BUTYLDIMETHYLSILYL ETHERS BY CHLORIDE-ION

Authors
FARRAS J SERRA C VILARRASA J
Citation
J. Farras et al., CLEAVAGE OF TERT-BUTYLDIMETHYLSILYL ETHERS BY CHLORIDE-ION, Tetrahedron letters, 39(3-4), 1998, pp. 327-330
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
3-4
Year of publication
1998
Pages
327 - 330
Database
ISI
SICI code
0040-4039(1998)39:3-4<327:COTEBC>2.0.ZU;2-Q
Abstract
A general method for the selective cleavage of tert-butyldimethylsilyl ethers in the presence of tert-butyldiphenylsilyl ones has been estab lished using a combination of H2O and a concentrated solution of LiCl in DMF at 90 degrees C. Since no acids, bases, reducing or oxidizing a gents are used, the method seems to be very appropriate for the deprot ection of TBDMS ethers in the presence of other sensitive functional g roups. (C) 1997 Elsevier Science Ltd. All rights reserved.