Abdominal and, specifically, hepatic abscesses have always been diffic
ult to diagnose clinically. The In-111 leukocyte scan has proven to be
a valuable modality assisting in the diagnosis of an abscess. The aut
hors present the case of a 64-year-old man who presented with vague cl
inical symptoms and inconclusive laboratory data for a hepatic abscess
. Both the ultrasound and CT scan were nondiagnostic; however, a disti
nct cold defect within the liver on an In-111 leukocyte scan resulted
in a liver biopsy, confirming the presence of an abscess. The potentia
l causes of cold defects on In-111 WBC scanning and the limitations of
this modality are discussed.