POSTOPERATIVE BLOOD-LOSS AFTER TRANSURETHRAL PROSTATECTOMY IS DEPENDENT ON IN-SITU FIBRINOLYSIS

Objective To evaluate whether post-operative blood loss in patients wi th benign prostatic hyperplasia, undergoing transurethral resection of the prostate (TURF), depends on in situ fibrinolysis in urine, and to determine the relative contributions of the urokinase and tissue-type plasminogen activator systems. Patients and methods TURF was performe d in 24 men (median age 68.5 years, range 52-78) and the weight of res ected tissue, the operative and post-operative blood loss determined, The concentrations of the urokinase- (u-PA) and tissue-type plasminoge n activator (t-PA)-related fibrinolysis in their urine was followed us ing sensitive and specific assays, and the changes related to post-ope rative blood loss. Measurements of the urinary concentrations of free t-PA activity, t-PA antigen, free u-PA activity, u-PA antigen and fibr in degradation products (FbDP) were determined and the area under the curve for each of these quantities correlated with the post-operative blood loss. Results The post-operative blood loss correlated significa ntly with the per-operative loss (P=0.047) and the weight of resected tissue (P=0.029). There was a highly significant correlation between t he area under the curve of FbDP in the urine and the post-operative bl ood loss (P<0.005), while there was no significant positive correlatio n between the PA concentration or activity in the urine and post-opera tive blood loss. There was a significant correlation between the urina ry t-PA activity and the amount of FbDP in the urine (P=0.047), and a significant correlation between the weight of resected tissue and the amount of FbDP in the urine (P=0.014). Conclusion The post-operative b lood loss after TURF is significantly related to an increase of the ur inary fibrinolytic activity and the enhanced fibrinolytic activity is probably caused by t-PA.