MUC6 GENE POLYMORPHISM IN HEALTHY-INDIVIDUALS AND IN GASTRIC-CANCER PATIENTS FROM NORTHERN PORTUGAL

Mucins exhibit a high degree of genetic polymorphism because of the pr esence of a variable number of tandem repeats, The aims of this work w ere to describe the MUC6 gene polymorphism in the Portuguese populatio n and to evaluate whether MUC6 gene polymorphism was involved in indiv idual susceptibility to gastric cancer development, as observed previo usly for the MUC1 gene, We found that the 10 alleles identified in the population of blood donors (n = 376), by Southern blot analysis, were also found in gastric cancer patients (n = 157), However, significant differences in allelic frequencies between the two populations were o bserved for 4 of the 10 alleles, in agreement with those described pre viously for the MUC1 gene; the largest allele was more frequent in blo od donors, and smaller alleles were more frequent in gastric cancer pa tients, Our results suggest that MUC6 gene polymorphism is involved in the predisposition to gastric carcinoma development.