BDNF AND NT-3 MODULATE EXPRESSION AND THREONINE PHOSPHORYLATION OF MICROTUBULE-ASSOCIATED PROTEIN-2 ANALOGS, AND ALTER THEIR DISTRIBUTION IN THE DEVELOPING RAT CEREBRAL-CORTEX

Authors
FUKUMITSU H OHASHI A NITTA A NOMOTO H FURUKAWA S
Citation
H. Fukumitsu et al., BDNF AND NT-3 MODULATE EXPRESSION AND THREONINE PHOSPHORYLATION OF MICROTUBULE-ASSOCIATED PROTEIN-2 ANALOGS, AND ALTER THEIR DISTRIBUTION IN THE DEVELOPING RAT CEREBRAL-CORTEX, Neuroscience letters, 238(3), 1997, pp. 107-110
Citations number
20
Categorie Soggetti
Neurosciences
Journal title
Neuroscience letters → ACNP
ISSN journal
03043940
Volume
238
Issue
3
Year of publication
1997
Pages
107 - 110
Database
ISI
SICI code
0304-3940(1997)238:3<107:BANMEA>2.0.ZU;2-Z
Abstract
Effects of brain-derived neurotrophic factor (BDNF) and neurotrophin ( NT)-3 on the expression of structural or synapse-associated proteins w ere examined in the developing rat cerebral cortex. Following ventricu lar administration of BDNF or NT-3 at embryonic day (E) 16, expression of microtubule-associated protein (MAP) 2 of 280 kDa was enhanced at E18 and/or E20, and threonine phosphorylation of MAP2 analogues of 120 and 66 kDa was modulated in different ways. NT-3 basically altered th e distribution of MAP2 proteins at E20. These findings suggest that NT -3 and BDNF play a role in regulating production and phosphorylation o f MAP2 analogues during development of the rat cerebral cortex. (C) 19 97 Elsevier Science Ireland Ltd.