KINETIC DISTRIBUTION OF CU, SE, AND ZN IN MICE DURING ASCITES TUMOR-BEARING PERIOD

The kinetic distribution of (CU)-C-64, Se-75, and Zn-69m radioactive t racers were determined in tissues of mice bearing ascites tumors and h ealthy ones. The HPGe gamma-ray spectrometric detection system was use d for radionuclide analysis in tissues which were sampled at various p eriods after tracer injection during ascitic tumor growth. Significant ly different distribution of (CU)-C-64, Se-75, and Zn-69m were found i n colon, small intestine, and liver of tumor-bearing mice. There was a dcerease of Se-75 in ascites and blood of tumor-bearing mice. The (CU )-C-64 and Zn-69m concentration varied significantly in kidneys, and a similar effect was observed in the spleen for (CU)-C-64, too. A disti nct variation of tracer distribution is also found at different stages after treatment. The results are discussed within the context of a co rrelation between elemental concentration and tumor-growth.