TC-99M-TEKHNETRIL (TC-99M-MIBI) LABELED WITH TC-99M FROM EXTRACTION AND SORPTION GENERATORS IN SCINTIGRAPHIC DIAGNOSTICS OF CORONARY-ARTERYDISEASE

Patients with coronary artery disease (CAD) and without coronary patho logy were studied by single-photon emission computed tomography (SPECT ) with Tekhnetril labeled with Tc-99m from extraction and sorption gen erators. MiBi labeled with Tc-99m prepared from extraction generator i s uniformly distributed over myocardial areas of the patients of refer ence groups both at rest and at peak of dipyridamole test. The differe nce in minimal and maximal accumulation of the radiopharmaceutical is no more that 30-40%, The sensitivity and specificity of CAD diagnosis by SPECT with Tekhnetril labeled with Tc-99m from extraction generator are 94 and 89% respectively. The myocardium scintigraphy with Tc-99m- Tekhnetril is the most sensitive for patients with CAD and previous my ocardial infarct and is almost independent of the number of affected c oronary arteries. The diagnostic properties of Tekhnetril labeled with Tc-99m from extraction and sorption generators are identical.