NO EVIDENCE OF ASSOCIATION BETWEEN DOPAMINE D-3 RECEPTOR GENE AND BIPOLAR AFFECTIVE-DISORDER

A recent study reported a possible association between allele 1 of the dopamine D-3 receptor gene and bipolar affective disorder using the h aplotype relative risk approach. In attempt to replicate these finding s, we used similar family-based methods, such as the Haplotype-Based H aplotype Relative Risk method and the Transmission Disequilibrium Test , in a sample of 44 bipolar probands from Sardinia with both parents a vailable, Using the Bal I restriction enzyme site polymorphism of Lann felt et al, (1992), no differences were found between transmitted and non-transmitted alleles and no evidence of linkage disequilibrium was observed, (C) 1997 Wiley-Liss, Inc.