GLYCOLIPIDS FROM SPONGES - 6 - PLAKOSIDE-A AND PLAKOSIDE-B, 2 UNIQUE PRENYLATED GLYCOSPHINGOLIPIDS WITH IMMUNOSUPPRESSIVE ACTIVITY FROM THEMARINE SPONGE PLAKORTIS SIMPLEX

Authors
COSTANTINO V FATTORUSSO E MANGONI A DIROSA M IANARO A
Citation
V. Costantino et al., GLYCOLIPIDS FROM SPONGES - 6 - PLAKOSIDE-A AND PLAKOSIDE-B, 2 UNIQUE PRENYLATED GLYCOSPHINGOLIPIDS WITH IMMUNOSUPPRESSIVE ACTIVITY FROM THEMARINE SPONGE PLAKORTIS SIMPLEX, Journal of the American Chemical Society, 119(51), 1997, pp. 12465-12470
Citations number
17
Journal title
Journal of the American Chemical Society → ACNP
ISSN journal
00027863
Volume
119
Issue
51
Year of publication
1997
Pages
12465 - 12470
Database
ISI
SICI code
0002-7863(1997)119:51<12465:GFS-6->2.0.ZU;2-1
Abstract
Plakoside A (la) and B (29), two unique glycosphingolipids belonging t o a new class of prenylated glycolipid, have been isolated from the ma rine sponge Plakortis simplex, and their structures have been determin ed by spectroscopic and chemical means. Plakosides are strongly immuno suppressive on activated T cells and proved to be useful natural model s for an improved comprehension of the structural requirements for imm unomodulating activity of glycosphingolipids.