ISOLATION OF HUMAN MANNAN-BINDING LECTIN, SERUM AMYLOID-P COMPONENT AND RELATED FACTORS FROM COHN FRACTION-III

Cohn Fraction III, a waste product of plasma fractionation, is a sourc e of several proteins involved in host defence as part of the innate i mmune system. Here a procedure is described for purifying mannan bindi ng lectin and serum amyloid P component to virtual homogeneity from Co hn Fraction I + III, and their separation from other mannan-binding fa ctors and from C-reactive protein. It is suggested that products deriv ed from Cohn Fraction III could have therapeutic potential, either for specific substitution therapy or as a combined package of innate immu ne factors.