RABBIT SPINAL-CORD INFARCTUATED UPON ALUMINUM (III)-LIPOSOMES INTRAVENOUS TREATMENT

The present paper describes toxic effects of liposomes containing alum inum lactate (AlLac(3)) (Al-liposomes) on rabbits spinal cord after in travenous treatment of 42 days with 60 mu g per day of metal-ion as Al Lac(3) at neutral pH as compared with an aqueous solution of the same metastable Al compound. Among the tissues examined, spinal cord appear to be the most injured one with large infarctual zones where Al is ac cumulated. Differently, the aqueous solution of AlLac(3) is ineffectiv e. Toxic aspects of Al lipophilic forms are herein discussed in terms of pharmacological implications.