CARCINOID-TUMOR AND INFLAMMATORY-BOWEL-DISEASE - A STUDY OF 11 CASES AND REVIEW OF THE LITERATURE

Objectives: To determine the frequency and outcome of carcinoid tumors ire a large series of patients with inflammatory bowel disease (IBD). Methods: Eleven patients with carcinoid tumors associated with IBD we re admitted or readmitted to The Mount Sinai Hospital between 1968 and 1995. These cases were derived from two sources, seven from our clini cal series of 3326 IBD patients (0.2%) and four more recent cases from the records of our Pathology Department. Six of the cases were associ ated with Crohn's disease and five with ulcerative colitis. Results: N ine of the 11 carcinoids were found in the appendix, and 2 were found in the ileum. All carcinoids were found incidentally after surgery for IBD; none of the patients had distant metastases or carcinoid syndrom e. Of the 11 cases, 3 were associated with an additional noncarcinoid tumor: 2 with adenocarcinoma of the colon and 1 with endometrial carci noma. Conclusions: There appears to he no evidence to substantiate a d irect association between IBD and carcinoid tumor, because almost all cases were found incidentally after surgery for IBD, with a frequency in operated IBD patients similar to that reported for patients without IBD.