2 LIMONOIDS FROM TURRAEA-OBTUSIFOLIA (MELIACEAE), PRIEURIANIN AND ROHITUKIN, ANTAGONIZE 20-HYDROXYECDYSONE ACTION IN A DROSOPHILA CELL-LINE

Authors
SARKER SD SAVCHENKO T WHITING P SIK V DINAN L
Citation
Sd. Sarker et al., 2 LIMONOIDS FROM TURRAEA-OBTUSIFOLIA (MELIACEAE), PRIEURIANIN AND ROHITUKIN, ANTAGONIZE 20-HYDROXYECDYSONE ACTION IN A DROSOPHILA CELL-LINE, Archives of insect biochemistry and physiology, 35(1-2), 1997, pp. 211-217
Citations number
24
Categorie Soggetti
Entomology,Biology,Physiology
Journal title
Archives of insect biochemistry and physiology → ACNP
ISSN journal
07394462
Volume
35
Issue
1-2
Year of publication
1997
Pages
211 - 217
Database
ISI
SICI code
0739-4462(1997)35:1-2<211:2LFT(P>2.0.ZU;2-T
Abstract
Bioassay-assisted HPLC analyses yielded two prieurianin-type limonoids , prieurianin and rohitukin, from the seeds of Turraea obtusifolia, wh ich act as antagonists oi 20-hydroxyecdysone action in the Drosophila melanogaster B-II cell line. With a 20-hydroxyecdysone concentration o f 5x10(-8) M, the ED50 values for prieurianin and rohitukin are 10(-5) M and 1.25x10(-4) M, respectively. (C) 1997 Wiley-Liss, Inc.