IMMUNIZATION OF AOTUS MONKEYS WITH RECOMBINANT PLASMODIUM-FALCIPARUM HYBRID PROTEINS DOES NOT REPRODUCIBLY RESULT IN PROTECTION FROM MALARIA INFECTION

Authors
KOCKEN CHM HUNDT E KNAPP B BRAZEL D ENDERS B NARUM DL WUBBEN JAM THOMAS AW
Citation
Chm. Kocken et al., IMMUNIZATION OF AOTUS MONKEYS WITH RECOMBINANT PLASMODIUM-FALCIPARUM HYBRID PROTEINS DOES NOT REPRODUCIBLY RESULT IN PROTECTION FROM MALARIA INFECTION, Infection and immunity, 66(1), 1998, pp. 373-375
Citations number
15
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
66
Issue
1
Year of publication
1998
Pages
373 - 375
Database
ISI
SICI code
0019-9567(1998)66:1<373:IOAMWR>2.0.ZU;2-W
Abstract
Plasmodium falciparum antigens SERF, HRPII, MSAI, and 41-3 have shown promise as vaccine components. This study aimed at reproducing and ext ending previous results using three hybrid molecules. Antibody respons es were reproduced in Aotus monkeys, but solid protection from a P. fa lciparum blood-stage challenge that showed an unintendedly enhanced pa thogenicity was not observed.