AN OVERVIEW AND RANKING OF BIOCHEMICAL MARKERS OF CARDIAC DISEASE - STRENGTHS AND LIMITATIONS

Much of the published evidence regarding the use of biochemical marker s in the acute coronary syndromes is contradictory, misleading, incomp lete, and unsatisfactory. There are several problems relating to analy zer calibration, reference ranges, decision thresholds, diagnostic gro upings, practice guidelines, and diagnostic gold standards. Ln additio n, much more rigor needs to be applied to test assessments, test use, and economic and decision analysis.