NEW RESOLVING BASES FOR IBUPROFEN AND MANDELIC-ACID - QUALIFICATION BY BINARY PHASE-DIAGRAMS

Authors
EBBERS EJ PLUM BJM ARIAANS GJA KAPTEIN B BROXTERMAN QB BRUGGINK A ZWANENBURG B
Citation
Ej. Ebbers et al., NEW RESOLVING BASES FOR IBUPROFEN AND MANDELIC-ACID - QUALIFICATION BY BINARY PHASE-DIAGRAMS, Tetrahedron : asymmetry, 8(24), 1997, pp. 4047-4057
Citations number
27
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
8
Issue
24
Year of publication
1997
Pages
4047 - 4057
Database
ISI
SICI code
0957-4166(1997)8:24<4047:NRBFIA>2.0.ZU;2-T
Abstract
New resolving bases for ibuprofen 1 and mandelic acid 2 were studied a nd qualified by their binary phase diagrams of the corresponding salts . It was shown that analysis of the binary phase diagrams gives a good prediction for a resolution process. A comparison of resolving bases revealed that (S)-phenylglycinol (S)-7 is the best resolving base for ibuprofen 1. By the same procedure, various resolving bases for mandel ic acid 2 were studied. The known resolving base (S)-MBA 9 was found t o be the best for this acid. (C) 1997 Elsevier Science Ltd. All rights reserved.