Am. Kvingedal et Eb. Smeland, A NOVEL PUTATIVE G-PROTEIN-COUPLED RECEPTOR EXPRESSED IN LUNG, HEART AND LYMPHOID-TISSUE, FEBS letters, 407(1), 1997, pp. 59-62
cDNA encoding a novel putative G-protein-coupled receptor, named LyGPR
(lymphocyte derived G-protein-coupled receptor) was cloned using a re
verse transcription-PCR approach, The LyGPR amino acid sequence is 375
residues long and shows similarity (about 30-35% identity) both to th
e angiotensin receptors and members of the chemokine receptor family,
Northern blot analysis revealed a 3.1-kb LyGPR transcript expressed pr
edominantly in lung, heart and lymphoid tissues, LyGPR expression was
also detected in the pre-B acute lymphoblastoid leukemia cell lines Re
h and Nalm-6, in the Burkitt's lymphoma line Daudi, and in hematopoiet
ic progenitor cells from bone marrow, as well as in B cells, T cells a
nd monocytes from peripheral blood. (C) 1997 Federation of European Bi
ochemical Societies.