TRANSURETHRAL PROSTATECTOMY IN PATIENTS WITH PREOPERATIVE BACTERIURIA- DOUBLE-BLIND-STUDY WITH ORAL FLEROXACIN AND CEFALEXIN

We compared oral fleroxacin and cefalexin in the prevention of postope rative infectious complications after transurethral prostatectomy (TUR P) in patients with preoperative bacteriuria. 95 patients underwent TU RP due to benign prostatic hyperplasia with preoperative bacteriuria. The therapy consisted of 7 days of oral fleroxacin 400 mg once a day o r cefalexin 500 mg three times daily. After 2 weeks, 62% of the urine samples were sterile in the fleroxacin group but only 37% in the cefal exin group (p = 0.047). Patients in the cefalexin group had also stati stically significantly more symptoms of urinary tract infections, Afte r 6 weeks, the bacterial eradication rate was 53% in the fleroxacin gr oup and 37% in the cefalexin group, There were no septicemias, TURP ca n be performed with reasonable safety with this oral anbiotic therapy.