SUCCESSFUL TREATMENT OF CYTOPHAGIC HISTIOCYTIC PANNICULITIS BY CYCLOSPORINE-A - A CASE-REPORT

This is a report of a case, 7 1/2 year-old-boy having chronic febrile and recurrent crops of painful subcutaneous nodules on lower extremiti es, which had previously been diagnosed as Weber-Christian disease, wh ich progressed to have cytophagic histiocytic activity in the skin, bo ne marrow with abnormal liver function and hemorrhagic diathesis. He w as subsequently treated with corticosteroid without good response. Aft er he was diagnosed as having cytophagic histiocytic panniculitis, cyc losporin A was administered intravenously in an initial dosage of 1 mg /kg/day and in oral maintenance dose of 10 recovered within 6 months w ith mild hypertension as an adverse effect.