A series of hydroxamic acids related to the non-selective matrix metal
loprotease inhibitor Batimastat is described, which inhibits the prote
olytic cleavage of the low affinity IgE receptor from cell membrane pr
eparations. Limited SAR studies suggest that the structural requiremen
ts for effective inhibition ate distinct from those required for the i
nhibition of collagenase. (C) 1997 Elsevier Science Ltd. All rights re
served.