SYNTHESIS AND BIOLOGICAL EVALUATION OF 3-ARYLISOQUINOLINES AS ANTITUMOR AGENTS

Authors
CHO WJ PARK MJ CHUNG BH LEE CO
Citation
Wj. Cho et al., SYNTHESIS AND BIOLOGICAL EVALUATION OF 3-ARYLISOQUINOLINES AS ANTITUMOR AGENTS, Bioorganic & medicinal chemistry letters, 8(1), 1998, pp. 41-46
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
1
Year of publication
1998
Pages
41 - 46
Database
ISI
SICI code
0960-894X(1998)8:1<41:SABEO3>2.0.ZU;2-1
Abstract
To investigate the structure-activity relationship of methylenedioxy-2 -vinylphenyl)isoquinolin-1(2H)-one 2, diverse substituted 3-arylisoqui nolines were synthesized and tested in vitro antitumor activity agains t five human tumor cell lines. The results showed a broad antitumor sp ectrum for a series of 3-arylisoquinolines. (C) 1997 Elsevier Science Ltd. All rights reserved.