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To investigate the structure-activity relationship of methylenedioxy-2
-vinylphenyl)isoquinolin-1(2H)-one 2, diverse substituted 3-arylisoqui
nolines were synthesized and tested in vitro antitumor activity agains
t five human tumor cell lines. The results showed a broad antitumor sp
ectrum for a series of 3-arylisoquinolines. (C) 1997 Elsevier Science
Ltd. All rights reserved.