HIGH-AFFINITY PHENYLGLYCINOL-BASED NK1 RECEPTOR ANTAGONISTS

Authors
OWENS AP HARRISON T MOSELEY JD SWAIN CJ SADOWSKI S CASCIERI MA
Citation
Ap. Owens et al., HIGH-AFFINITY PHENYLGLYCINOL-BASED NK1 RECEPTOR ANTAGONISTS, Bioorganic & medicinal chemistry letters, 8(1), 1998, pp. 51-56
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
1
Year of publication
1998
Pages
51 - 56
Database
ISI
SICI code
0960-894X(1998)8:1<51:HPNRA>2.0.ZU;2-4
Abstract
Heterocyclic replacements for the carboxamido group of the previously disclosed phenylglycinol-based human NK1 (hNK(1)) receptor antagonists have been investigated, ultimately leading to acyclic compounds with sub-nanomolar affinity for the hNK(1) receptor. (C) 1997 Elsevier Scie nce Ltd. All rights reserved.