5-AMINOMETHYLQUINOXALINE-2,3-DIONES - PART I - A NOVEL CLASS OF AMPA RECEPTOR ANTAGONISTS

Authors
AUBERSON YP BISCHOFF S MORETTI R SCHMUTZ M VEENSTRA SJ
Citation
Yp. Auberson et al., 5-AMINOMETHYLQUINOXALINE-2,3-DIONES - PART I - A NOVEL CLASS OF AMPA RECEPTOR ANTAGONISTS, Bioorganic & medicinal chemistry letters, 8(1), 1998, pp. 65-70
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
1
Year of publication
1998
Pages
65 - 70
Database
ISI
SICI code
0960-894X(1998)8:1<65:5-PI-A>2.0.ZU;2-P
Abstract
A series of 5-aminomethylquinoxaline-2,3-diones have been identified a s potent and selective AMPA antagonists. Some of these compounds are a lso active at the glycine-binding site of the NMDA receptors. A number of these novel, water-soluble quinoxaline-2,3-dione derivatives displ ay protective effects in the electroshock-induced convulsion model in mice. (C) 1997 Elsevier Science Ltd. All rights reserved.