DISCOVERY OF FR115092 - A NOVEL ANTINEPHRITIC AGENT

Authors
OGINO T TSUJI K TOJO T IGARI N SEKI N SUDO Y MANDA T NISHIGAKI F MATSUO M
Citation
T. Ogino et al., DISCOVERY OF FR115092 - A NOVEL ANTINEPHRITIC AGENT, Bioorganic & medicinal chemistry letters, 8(1), 1998, pp. 75-80
Citations number
26
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
1
Year of publication
1998
Pages
75 - 80
Database
ISI
SICI code
0960-894X(1998)8:1<75:DOF-AN>2.0.ZU;2-U
Abstract
A series of dapsone-related 4-aminophenyl and 2-aminothiazolyl derivat ives was prepared, and their antinephritic activity and blood toxicity were evaluated. 5-(2-Pyridylsulfonyl)-2-thiazolamine (FR115092, 26) w as effective against two nephritis models, namely graft-versus-host di sease (GVHD) and autoimmune W/BF1 mice, and showed none of the blood t oxicity observed with dapsone. (C) 1997 Elsevier Science Ltd. All righ ts reserved.