DNA GYRASE INHIBITORY ACTIVITY OF ELLAGIC ACID-DERIVATIVES

Authors
WEIDNERWELLS MA ALTOM J FERNANDEZ J FRAGASPANO SA HILLIARD J OHEMENG K BARRETT JF
Citation
Ma. Weidnerwells et al., DNA GYRASE INHIBITORY ACTIVITY OF ELLAGIC ACID-DERIVATIVES, Bioorganic & medicinal chemistry letters, 8(1), 1998, pp. 97-100
Citations number
9
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
1
Year of publication
1998
Pages
97 - 100
Database
ISI
SICI code
0960-894X(1998)8:1<97:DGIAOE>2.0.ZU;2-N
Abstract
Ellagic acid was found to inhibit E. coli DNA gyrase supercoiling with approximately the same potency as nalidixic acid. Tricyclic analogs o f ellagic acid, which vary in the number and position of the hydroxy g roups as well as their replacement with halogens, have been synthesize d. The biological activity of these analogs is discussed. (C) 1997 Els evier Science Ltd. All rights reserved.