M. Kiuchi et al., SYNTHESIS AND BIOLOGICAL EVALUATION OF 2,2-DISUBSTITUTED 2-AMINOETHANOLS - ANALOGS OF FTY720, Bioorganic & medicinal chemistry letters, 8(1), 1998, pp. 101-106
Desymmerization of symmetric FTY720 by substitution of different alkyl
groups for one of the prochiral hydroxymethyl groups was performed. T
he size of the alkyl groups and the absolute configuration at quaterna
ry carbon were important on immunosuppressive activity. (C) 1997 Elsev
ier Science Ltd. All rights reserved.