SYNTHESIS AND BIOLOGICAL EVALUATION OF 2,2-DISUBSTITUTED 2-AMINOETHANOLS - ANALOGS OF FTY720

Authors
KIUCHI M ADACHI K KOHARA T TESHIMA K MASUBUCHI Y MISHINA T FUJITA T
Citation
M. Kiuchi et al., SYNTHESIS AND BIOLOGICAL EVALUATION OF 2,2-DISUBSTITUTED 2-AMINOETHANOLS - ANALOGS OF FTY720, Bioorganic & medicinal chemistry letters, 8(1), 1998, pp. 101-106
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
1
Year of publication
1998
Pages
101 - 106
Database
ISI
SICI code
0960-894X(1998)8:1<101:SABEO2>2.0.ZU;2-#
Abstract
Desymmerization of symmetric FTY720 by substitution of different alkyl groups for one of the prochiral hydroxymethyl groups was performed. T he size of the alkyl groups and the absolute configuration at quaterna ry carbon were important on immunosuppressive activity. (C) 1997 Elsev ier Science Ltd. All rights reserved.