COMPARISON OF CO2 GENERATION (BACTEC) AND VIABLE-COUNT METHODS TO DETERMINE THE POSTANTIBIOTIC EFFECT OF ANTIMYCOBACTERIAL AGENTS AGAINST MYCOBACTERIUM-AVIUM COMPLEX
Gg. Zhanel et al., COMPARISON OF CO2 GENERATION (BACTEC) AND VIABLE-COUNT METHODS TO DETERMINE THE POSTANTIBIOTIC EFFECT OF ANTIMYCOBACTERIAL AGENTS AGAINST MYCOBACTERIUM-AVIUM COMPLEX, Antimicrobial agents and chemotherapy, 42(1), 1998, pp. 184-187
The postantibiotic effects (PAEs) of antimycobacterial agents determin
ed with a BACTEC TB-460 instrument (CO2 production) and by a tradition
al viable-count method against Mycobacterium avium complex (MAC) were
not significantly different (P > 0.05). The longest PAEs following a 2
-h exposure to 2x the MIC were induced by amikacin (10.3 h), rifampin
(9.7 h), and rifabutin (9.5 h), while the shortest PAEs resulted from
clofazimine (1.7 h) and ethambutol (1.1 h) exposure. CO2 generation is
a valid and efficient means of determining in vitro PAEs against MAC.