COMPARISON OF CO2 GENERATION (BACTEC) AND VIABLE-COUNT METHODS TO DETERMINE THE POSTANTIBIOTIC EFFECT OF ANTIMYCOBACTERIAL AGENTS AGAINST MYCOBACTERIUM-AVIUM COMPLEX

Authors
ZHANEL GG SAUNDERS MH WOLFE JN HOBAN DJ KARLOWSKY JA KABANI AM
Citation
Gg. Zhanel et al., COMPARISON OF CO2 GENERATION (BACTEC) AND VIABLE-COUNT METHODS TO DETERMINE THE POSTANTIBIOTIC EFFECT OF ANTIMYCOBACTERIAL AGENTS AGAINST MYCOBACTERIUM-AVIUM COMPLEX, Antimicrobial agents and chemotherapy, 42(1), 1998, pp. 184-187
Citations number
17
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
42
Issue
1
Year of publication
1998
Pages
184 - 187
Database
ISI
SICI code
0066-4804(1998)42:1<184:COCG(A>2.0.ZU;2-Z
Abstract
The postantibiotic effects (PAEs) of antimycobacterial agents determin ed with a BACTEC TB-460 instrument (CO2 production) and by a tradition al viable-count method against Mycobacterium avium complex (MAC) were not significantly different (P > 0.05). The longest PAEs following a 2 -h exposure to 2x the MIC were induced by amikacin (10.3 h), rifampin (9.7 h), and rifabutin (9.5 h), while the shortest PAEs resulted from clofazimine (1.7 h) and ethambutol (1.1 h) exposure. CO2 generation is a valid and efficient means of determining in vitro PAEs against MAC.