ANTIPLASMODIAL TRITERPENE FROM VERNONIA-BRASILIANA

Citation
Tmd. Alves et al., ANTIPLASMODIAL TRITERPENE FROM VERNONIA-BRASILIANA, Planta medica, 63(6), 1997, pp. 554-555
Citations number
14
Categorie Soggetti
Pharmacology & Pharmacy","Plant Sciences","Chemistry Medicinal
Journal title
ISSN journal
00320943
Volume
63
Issue
6
Year of publication
1997
Pages
554 - 555
Database
ISI
SICI code
0032-0943(1997)63:6<554:ATFV>2.0.ZU;2-E
Abstract
The hexane extract from leaves of Vernonia brasiliana (L.) Druce (Comp ositae) was active in vitro against Plasmodium folciparum and in vivo in mice infected with Plasmodium berghei. This extract was subjected t o a bioassay-guided fractionation protocol based on the in vitro model . Lupeol was identified as a compound responsible for the activity, in hibiting the P. falciparum growth by 45 % when tested at 25 mu g/ml. H owever, this triterpene was inactive in vivo when 15 mg/kg were admini stered per os during four consecutive days to mice infected with P. be rghei. beta-Amyrin and germanicol, isolated from the same fraction tha t yielded lupeol, were inactive in the in vitro assay.