RAT TYROSINE-HYDROXYLASE GENE POLYMORPHISMS

Authors
MURRU S PANI L PODDIE D GESSA G CAO A PIRASTU M
Citation
S. Murru et al., RAT TYROSINE-HYDROXYLASE GENE POLYMORPHISMS, Molecular brain research, 45(2), 1997, pp. 345-348
Citations number
14
Categorie Soggetti
Neurosciences
Journal title
Molecular brain research → ACNP
ISSN journal
0169328X
Volume
45
Issue
2
Year of publication
1997
Pages
345 - 348
Database
ISI
SICI code
0169-328X(1997)45:2<345:RTGP>2.0.ZU;2-T
Abstract
The rat tyrosine hydroxylase gene (TH) from a panel of outbred and inb red rat strains has been analysed by Southern blotting, restriction-en donuclease mapping and direct sequencing of PCR-amplified products for detecting DNA polymorphisms. Five polymorphic sites have been charact erized. This information may be used in pharmacogenetic studies to det ermine the influence of the TH gene in animal models of affective diso rders and addictive behaviours. (C) 1997 Elsevier Science B.V.