RENAL EFFECTS OF WATER-SOLUBLE POLYARYLSULFONATED C-60 IN RATS WITH AN ACUTE TOXICITY STUDY

Authors
CHEN HHC YU C UENG TH LIANG CT CHEN BJ HONG CC CHIANG LY
Citation
Hhc. Chen et al., RENAL EFFECTS OF WATER-SOLUBLE POLYARYLSULFONATED C-60 IN RATS WITH AN ACUTE TOXICITY STUDY, Fullerene science and technology, 5(7), 1997, pp. 1387-1396
Citations number
14
Journal title
Fullerene science and technology → ACNP
ISSN journal
1064122X
Volume
5
Issue
7
Year of publication
1997
Pages
1387 - 1396
Database
ISI
SICI code
1064-122X(1997)5:7<1387:REOWPC>2.0.ZU;2-O
Abstract
Acute toxicity study of water soluble C-60 was conducted in young fema le rats with one dose intraperitoneal injection of C-60 ((CH2)(4)SO3Na )(4-6). The preliminary results indicated its LD50 value as approximat ely 600 mg/kg. The compound induced a unique phagolysosome-overload ne phropathy that may serve as a biological marker in toxicity screening test for a series of synthesized water-soluble fullerenes.