Ds. Pine et al., THE RISK FOR EARLY-ADULTHOOD ANXIETY AND DEPRESSIVE-DISORDERS IN ADOLESCENTS WITH ANXIETY AND DEPRESSIVE-DISORDERS, Archives of general psychiatry, 55(1), 1998, pp. 56-64
Background: Various studies find relationships among anxiety and depre
ssive disorders of adolescence and adulthood. This study prospectively
examines the magnitude of longitudinal associations between adolescen
t and adult anxiety or depressive disorders. Methods: An epidemiologic
ally selected sample of 776 young people living in upstate New York re
ceived DSM-based psychiatric assessments in 1983, 1985, and 1992 using
structured interviews. The magnitude of the association between adole
scent and adult anxiety or depressive disorders was quantified using o
dds ratios generated from logistic regression analyses and from a set
of latent Markov analyses. We focus on longitudinal associations among
narrowly defined DSM anxiety or depressive disorders. Results: In sim
ple logistic models, adolescent anxiety or depressive disorders predic
ted an approximate 2- to 3-fold increased risk for adulthood anxiety o
r depressive disorders. There was evidence of specificity in the cours
e of simple and social phobia but less specificity in the course of ot
her disorders. Results from the analyses using latent variables sugges
ted that while most adolescent disorders were no longer present in you
ng adulthood, most adult disorders were preceded by adolescent disorde
rs. Conclusions: An anxiety or depressive disorder during adolescence
confers a strong risk for recurrent anxiety or depressive disorders du
ring early adulthood. Most anxiety and depressive disorders in young a
dults may be preceded by anxiety or depression in adolescence.