Thirteen patients were retrospectively identified with the electrodiag
nostic pattern of combined L5 radiculopathy by needle electrode examin
ation, and abnormality of the superficial peroneal nerve (SPN) sensory
nerve action potential (SNAP) amplitude. To have combined L5-derived
sensory and motor axon loss, lesions must be localized at or distal to
the L5 dorsal root ganglion (DRG), but also proximal to the sacral pl
exus. Six patients had evidence of an active intraspinal canal (ISC) l
esion, 3 had diabetes, and 4 had nonspecific causes. The ISC localizat
ion in at least 6 of our cases is counter to the commonly held electro
diagnostic dogma that L5 radiculopathy spares the SPN SNAP, but recent
anatomic studies confirm the ISC location of up to 40% of L5 DRG. Thu
s loss of the SPN SNAP does not exclude ISC lesions. Published by John
Wiley & Sons, Inc. (C) 1998 John Wiley & Sons, Inc.