RISKS FOR SENSORIMOTOR PERIPHERAL NEUROPATHY AND AUTONOMIC NEUROPATHYIN NON-INSULIN-DEPENDENT DIABETES-MELLITUS (NIDDM)

identification of risk factors for development of diabetic sensorimoto r peripheral neuropathy (DSPN) and diabetic autonomic neuropathy (DNA) may help to prevent or modify these complications. The ABCD Trial, a prospective study of diabetic complications, has identified risk facto rs of the presence and staging of peripheral neuropathy based on neuro logical symptom scores, neurological disability scores, autonomic func tion testing and quantitative sensory examination. DSPN is independent ly associated with diabetes duration [odds ratio (OR) = 1.5 per 10 yea rs], body weight (OR = 1.1 per 5 kg), age (OR = 1.8 per 10 years), ret inopathy (OR = 2.3), overt albuminuria (OR = 2.5), height (OR = 1.2 pe r 10 cm), duration of hypertension (OR = 1.1 per 10 years), insulin us e (OR = 1.4), and race/ethnicity [African American vs. non-Hispanic wh ite (OR = 0.4) and Hispanic vs. nonHispanic white (OR = 0.8)], DAN is independently associated with diabetes duration (OR = 1.2 per 10 years ), body weight (OR = 1.1 per 5 kg), glycosylated hemoglobin (OR = 1.1 per 2.5%), overt albuminuria (OR = 1.6), and retinopathy (OR = 1.8). ( C) 1998 John Wiley & Sons, Inc.