REFRACTORY BREAST-CANCER - A COMPARISON OF 2 DIFFERENT CHEMOTHERAPY REGIMENS

Sixty metastatic and recurrent breast cancer patients who had been giv en cyclophosphamide, methotrexate and fluorouracil (CMF) therapy previ ously and were treated at the Oncology Departments of Cukurova and Ege University Medical Schools between March 1992-94, were randomized int o 2 groups for the chemotherapy program, The 30 patients in the Ist gr oup were given etoposide: 200 mg x day x 5 days orally every 3 weeks. The 30 patients of the 2nd group were given fluorouracil: 500 mg x m(2 ), doxorubicin: 50mg/m(2), cyclophosphamide: 500 mg/m(2) intravenously every 3 weeks, The response rates were 21/30 in group 1 and 17/30 in group 2. The median duration of responses was 11 months (8-21) in the Ist and 3 months (4-18) in the 2nd group. Severe myelotoxicity was obs erved in 2 of the patients in the Ist group and in 5 of the patients i n the 2nd group.