PROGNOSTIC VALUE OF HLA-DR EXPRESSION AND DENDRITIC CELL INFILTRATIONIN GASTRIC-CANCER

We attempted to correlate the expression of human leukocyte antigen DR (HLA-DR) and tumor infiltration by S-100-protein-positive dendritic c ells with clinicopathologic features in 165 patients with gastric canc er. The expression of HLA-DR was correlated with the histologic type, Infiltration of dendritic cells correlated negatively with distant lym ph node metastases, clinical stage, and peritoneal invasion, There was no correlation between the expression of HLA-DR and infiltration by d endritic cells, In patients with resectable gastric cancer, the grade of infiltrating dendritic cells may be a suitable predictor of prognos is.