M. Brzosko et al., EFFECTS OF IONIC AND NONIONIC CONTRAST-MEDIA ON PLATELET-FUNCTION AS EVALUATED BY PLASMA-CONCENTRATION OF BETA-THROMBOGLOBULIN, British journal of radiology, 70(840), 1997, pp. 1239-1244
The aim of the study was to evaluate the effects of ionic and non-ioni
c contrast media on platelet function. In 44 patients who underwent an
giography, the plasma concentration of beta-thromboglobulin (beta TG)
was measured before and after ionic contrast medium (diatrizoate) admi
nistration in 22 patients and non-ionic contrast medium (iopromide) in
the other 22 patients. A significant decrease in the plasma beta TG l
evels after intraarterial contrast medium injection occurred in both g
roups of patients. No significant beta TG level changes occurred in pa
tients with normal pre-examination beta TG levels in both groups. In p
atients with elevated beta TG levels before arteriography, beta TG ret
urned to normal values after contrast medium injection in both groups.
There was no significant correlation between the amount of administer
ed contrast medium and beta TG concentration after angiography. These
results suggest that platelet function is not affected by either ionic
or non-ionic contrast medium in patients with normal platelet activat
ion. In patients with enhanced platelet activation, the activation bec
ame normal after contrast medium administration.