THE AGED SUPRACHIASMATIC NUCLEUS IS PHASE-SHIFTED BY CAMP IN-VITRO

Authors
RUBY NF EDGAR DM HELLER HC MILLER JD
Citation
Nf. Ruby et al., THE AGED SUPRACHIASMATIC NUCLEUS IS PHASE-SHIFTED BY CAMP IN-VITRO, Brain research, 779(1-2), 1998, pp. 338-341
Citations number
23
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
779
Issue
1-2
Year of publication
1998
Pages
338 - 341
Database
ISI
SICI code
0006-8993(1998)779:1-2<338:TASNIP>2.0.ZU;2-P
Abstract
The cyclic adenosine monophosphate (cAMP) analog, 8-bromo-cAMP, phase advanced circadian neuronal rhythms in both aged and adult rat suprach iasmatic nuclei (SCN) by approximate to 2 h in vitro. Rhythm amplitude was 20% lower in aged compared to adult SCN. The diminished efficacy of serotonergic agonists to phase shift behavioral rhythms of aged ani mals may be due to decrements in signal transduction mechanisms proxim al to cAMP. (C) 1998 Elsevier Science B.V.