OCCLUSION OF THE ADRENAL VEIN LEADS TO AN INCREASE IN RENAL VASCULAR-RESISTANCE IN THE IPSILATERAL KIDNEY

1, The aim of the present study was to investigate the effect of an ac ute increase in blood flow through the adrenal-renal vascular connecti on (ARVC), due to occlusion of the adrenal vein, on renal blood flow ( RBF) and renal vascular resistance (RVR), 2, Experiments were performe d in Wistar-Kyoto rats, Animals were divided into four groups, In the first group, the adrenal vein was clamped using a metal clip, In the s econd group, the tissue between the adrenal gland and the kidney was c ut before clamping, In I-he third and fourth groups, alpha-adrenocepto r blockade was inducted bg intravenous infusion of phentolamine before clamping the adrenal vein, In addition, in the fourth group, tissue b et treen the adrenal gland and the kidney was cut before clamping, 3, In the first group, occlusion of the adrenal vein caused an increase i n RVR, followed by a decrease in RBF, In the second, third and fourth groups, the same procedure did not change either RBF or RVR. 4, We con clude that the augmented inflow of catecholamines to the kidney throug h the ARVC changes the haemodynamics of the kidney and may contribute to development of arterial hypertension due to occlusion of the adrena l vein.