Red cell substitutes are developing rapidly and progressing in their c
linical testing. The original concept of a shelf storable oxygen carry
ing solution for use in trauma and other emergency situations still re
mains valid. Of interest is the potential for red cell substitutes to
be used in other areas of surgery, traditionally the realm of autologo
us transfusion This article describes some of the logic behind definin
g which areas of application are potentially useful in the surgical ar
ena.