RETROVIRAL GENE-THERAPY IN HEMATOPOIETIC DISEASES

A number of diverse gene therapy strategies are being evaluated in the search for novel therapeutic approaches to hematopoietic disease. In this review, we will limit our discussion to three areas of active res earch: the treatment of genetic diseases, the use of drug resistance g ene vectors in autologous transplantation, and tumor immunization stra tegies in cancer. Although gene delivery remains a major challenge to gene therapy, recent modifications which improve gene transfer will al so be addressed. (C) 1997 Wiley-Liss, Inc.