TACHYCARDIA, ORTHOSTATIC HYPOTENSION AND PROFOUND WEAKNESS DUE TO CONCOMITANT USE OF FLUOXETINE AND NIFEDIPINE

Authors
AZAZLIVSHITS TLT DANENBERG HD
Citation
Tlt. Azazlivshits et Hd. Danenberg, TACHYCARDIA, ORTHOSTATIC HYPOTENSION AND PROFOUND WEAKNESS DUE TO CONCOMITANT USE OF FLUOXETINE AND NIFEDIPINE, Pharmacopsychiatry, 30(6), 1997, pp. 274-275
Citations number
15
Categorie Soggetti
Psychiatry,"Pharmacology & Pharmacy
Journal title
Pharmacopsychiatry → ACNP
ISSN journal
01763679
Volume
30
Issue
6
Year of publication
1997
Pages
274 - 275
Database
ISI
SICI code
0176-3679(1997)30:6<274:TOHAPW>2.0.ZU;2-U
Abstract
The use of the selective serotonin reuptake inhibitor fluoxetine is as sociated with only minor cardiovascular effects. However, due to a pos sible inhibitory effect on the metabolism of calcium channel blockers it may potentiate the activity of nifedipine, causing profound adverse cardiovascular effects. This report describes the appearance of profo und weakness, orthostatic hypotension and tachycardia following the in itiation of fluoxetine treatment in a nifedipine-treated 80-year-old p atient.