OCCURRENCE AND SPONTANEOUS REMISSION OF GRAVES HYPERTHYROIDISM PRECEDED BY PAINLESS THYROIDITIS

A 45-year-old woman was referred to our hospital because of discomfort in the cervical region. Laboratory findings revealed thyrotoxicosis w ith positive TSH receptor antibodies, but acute inflammatory data were absent. After three weeks the thyroid hormone levels spontaneously de creased to hypothyroid levels, and thyroidal radioactive iodine uptake (RAIU) was below normal. A needle-biopsy specimen of the thyroid glan d obtained two months later showed diffuse lymphocytic thyroiditis, an d she was therefore diagnosed as having had painless thyroiditis. Two months after returning to euthyroidism, a second thyrotoxicosis develo ped. TSH receptor antibodies remained positive, but RAIU was slightly above normal, indicating Graves' hyperthyroidism. Treatment with antit hyroidal drugs was commenced but was soon discontinued due to an aller gic reaction. Although only beta-adrenergic antagonist was administere d for treating the thyrotoxicosis, thyroid function was gradually norm alized in parallel with the reduction in TSH receptor antibody. In thi s case, painless thyroiditis would be followed by Graves' disease and subsequent spontaneous remission.