IMMUNE-SYSTEM ACTIVATION BY CISPLATIN AND ITS ANALOG POLY-PLAT - AN IN-VITRO AND IN-VIVO STUDY

Swiss Webster mice treated with bolus injections of 'poly-plat' (10 mg /kg) show increased macrophage activation after 2 and 12 days when iso lated in cultures. Such macrophages demonstrate an increase in the num ber of lysosomes and cytoplasmic extension formation with enhanced cyt okine (interleukin-1 alpha) activity. In addition, peripheral blood sm ears demonstrated an increase in lymphocytes and monocytes compared to cisplatin-treated animals. These results show that 'poly-plat' activa tes the immune system more effectively than cisplatin both in vitro an d in vivo. [(C) 1998 Rapid Science Ltd.].